Turning CD34 Non-Mobilizers into Mobilizers: A Case Report Involving Plerixafor (AMD3100)
نویسندگان
چکیده
منابع مشابه
Turning CD34 Non-Mobilizers into Mobilizers: A Case Report Involving Plerixafor (AMD3100).
SUMMARY: OBJECTIVE: In a significant proportion of patients with hematologic malignancies (5-30%) poor mobilization of hematopoietic stem cells (HSC) is observed. This compromises the application of effective and potentially curative high-dose chemotherapy (HDC) treatment. CASE REPORT: Here we report the case of a 38-year-old female patient who was treated for recurrent follicular B-cell non-Ho...
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BACKGROUND Granulocyte-colony-stimulating factor (G-CSF) is routinely used for mobilization of hematopoietic stem and progenitor cells preceding autologous transplantation after high-dose chemotherapy in hematologic malignancies. However, due to high mobilization failure rates, alternative mobilization strategies are required. STUDY DESIGN AND METHODS Patients who poorly mobilized CD34+ hemat...
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Helitrons are a recently discovered superfamily of eukaryotic transposable elements. They are known for their ability to capture and mobilize gene fragments and, in turn, significantly contribute to the lack of gene colinearity widely reported among different maize inbred lines. As judged by present evidence, Helitrons differ fundamentally from Class I and Class II families of transposable elem...
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. http://dx.doi.org/10.5045/kjh.2011.46.4.209 The Korean Journal of Hematology Volume 46ᆞNumbe...
متن کاملHow I treat patients who mobilize hematopoietic stem cells poorly.
Transplantation with 2-5 × 10(6) mobilized CD34(+)cells/kg body weight lowers transplantation costs and mortality. Mobilization is most commonly performed with recombinant human G-CSF with or without chemotherapy, but a proportion of patients/donors fail to mobilize sufficient cells. BM disease, prior treatment, and age are factors influencing mobilization, but genetics also contributes. Mobili...
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ژورنال
عنوان ژورنال: Transfusion Medicine and Hemotherapy
سال: 2009
ISSN: 1660-3818,1660-3796
DOI: 10.1159/000235954